![]() In the case of ROCF delayed recall, Ecstasy users carrying the COMT val/val + 5-HTT L genotype also perform poorer than nonusers carrying identical combination of genes. Moreover, for ROCF immediate recall, Ecstasy users carrying the COMT val/val and 5-HTT S/S genotype (irrespective of the intensity of MDMA use) perform more poorly than nonusers carrying the same genotype. Results indicate that heavy Ecstasy users carrying the 5-HTT S/S and COMT val/val genotypes have poorer performances on tests of speed/attentional control (Digit Symbol) and visual attention and organization ( Rey-Osterrieth complex figure (ROCF) Copy). The findings from the study of the combined influence of COMT and 5-HTT genes on the cognitive performance of Ecstasy users with varying levels of drug exposure has revealed relevant aggregate effects of “at-risk” polymorphisms from both genes. Some of the limitations that reduce the significance of the early studies on MDMA∗gene interactions are the lack of substantially large diverse samples to characterize dose∗gene interactions, and the isolated study of individual gene polymorphisms, instead of combinations of relevant genes that may influence cognition in an additive or synergic fashion. Ricardo Pardo, in Biological Research on Addiction, 2013 Genes ( COMT and 5-HTT) × Environment Interaction
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